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Name: | Edaravone | Chemical Name: | 5 - Methyl - 2 - Phenyl - 4H - Pyrzol - 3 - One |
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CAS: | 89-25-8 | Molecular Formula: | C10H10N2O |
High Light: | 668270 12 0,274693 27 5 |
Edaravone CAS : 89-25-8 5 - Methyl - 2 - phenyl - 4H - pyrazol - 3 - one
Name : Edaravone
Synonym : MCI-186
CAS No . : 89-25-8
Chemical Name : 5 - Methyl - 2 - phenyl - 4H - pyrazol - 3 - one ; 3 - metyl - 1 - phenyl - 2 - pyrazolin - 5 - one
Molecular Formula : C10H10N2O
Molecular Weight : 174.2
Description :
Edaravone is the active pharmaceutical ingredient of the brand drug names Radicava and Radicut. It belongs to the drug class miscellaneous central nervous system agent and is used to treat Amyotrophic Lateral Sclerosis ( ALS ). It is an antioxidant. Oxidative stress is might to be part of the process kills neurons in people with amyotrophic lateral sclerosis. It is also used to help recovery form stroke in Japan.
In late 1980s free radical scavenger edaravone was first developed to treat stroke to prevent the swelling of the brain. Mitsubishi Pharma marketed it in 2001 in Japan. Mitsubishi Tanabe started phase III clnical trial for amyotrophic lateral sclerosis ( ALS ) in 2011. Japan approved this use in 2015. FDA and EU granted the company the Orphan Drug Designation for edaravone in 2016. US FDA approved it to treat ALS in May 2017.
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