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Sitagliptin Phosphate CAS : 654671-78-0 GMP not commercial sold to patent protection area
Name : Sitagliptin Phosphate monohydrate
Chemical Name : 7 - [ ( 3R ) - 3 - amino - 1 - oxo - 4 - ( 2 , 4 , 5 - trifluorophenyl ) butyl ] - 5 , 6 , 7 , 8 - tetrahydro - 3 - ( trifluoromethyl ) - 1 , 2 , 4 - triazolo [ 4 , 3-a ] pyrazine phosphate ( 1 : 1 ) monohydrate
CAS No . : 654671-78-0
Molecular Formula : C16H15F6N5O•H3PO4•H2O
Molecular Weight : 523.32
Sitagliptin phosphate monohydrate is the active pharmaceutical ingredient of Januvia which is used to treat diabets mellitus type II. It is an oral antihyperglycemic of the DPP-4 ( dipeptidy peptidase-4) inhibitor class. It is a white to off-white, non-hygroscopic crystalline powder soluble in water and DMF, slightly soluble in methanol. It is insoluble in isopropanol and isopropyl acetate.
It was developed and is marketed by Merck & Co. (also known as MSD outside USA). Its brand drug Januvia annual sales in USA in 2016 is USD2.29 billion.
Sitagliptin phosphate monohydrate is still protected by patents in some countries and areas. We only sell small quantities to these areas for R&D purpose and do not sell to these countries and areas commercially.