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CAS No. : 147118-37-4 Rosuvastatin Intermediate 4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidine-5-carboxaldehyde
Chemical Name : 4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidine-5-carboxaldehyde
CAS No. : 147118-37-4
Short code: Z8
Molecular Formula : C16H18FN3O3S
Usage: Rosuvastatin Intermediate
Appearance: White or off-white powder or crystalline powder
MP: 175-182 Deg C
Loss on drying: NMT 1.0%
Related substances: NMT 1.0%
Purity: NLT 99.0%
Description: Rosuvastatin Calcium is the active ingredient (API) of branded drug Crestor. It was innovated by the Japanese drug maker Shionogi and cooperated the marketing with AstraZeneca. Rosuvastatin Calcium is the new generation of statins drugs after Lovastatin, Simvastatin and Atorvastatin. It is a fully synthesized product and used to treat high cholesterol and to prevent cardiovascular disease. Some persons also call it super statin to express its good effect. The annual sales of Crestor exceed US dollars 6.6 Billion in 2014. The first generic version of Crestor will launch in US in 2016.
PYRIMIDINE-5-YL]CARBALDEHYDE CAS No. 147118-37-4 is one of its intermediates. There are several synthesis routes to manufacture this intermediate but some routes are protected by the patents in some countries including Europe, USA and China. We strictly obey the laws and our commercial products are manufactured without infringing such patents. But anyway, the buyers should know the patent status by themselves. We promise to supply the real route of synthesis to the buyers. The buyers should take the risks of patent infringement by themselves.
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