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|Usage:||Rosuvastatin Calcium Intermediate||CAS:||154026-95-6|
|Short Code:||D - 5|
CAS No . : 154026-95-6 Rosuvastatin intermediate D - 5 Assay 98 % Min Optical Purity 98 % Min
Chemical Name: (4R-Cis)-6-((Acetyloxy)methyl)-2,2-dimethy-1,3-dioxane-4-acetic acid, 1,1-dimethylethyl ester:
Synonym: (4R-Cis)-6-((Acetyloxy)methyl)-2,2-dimethyl-1,3-dioxane-4-acetic acid, tert - butyl ester
Tert - butyl (4R-Cis)-6-((Acetyloxy)methyl)-2,2-dimethyl-1,3-dioxane-4-acetate
CAS No. 154026-95-6
Molecular Formaula : C15H26O6
Molecular Weight : 302.36
Usage: Rosuvastatin calcium intermediate
Appearance : White or off-white crystal
Assay > 98 %
Optical Purity: 98 %
Moisture : 0.5 % max
(4R-Cis)-6-((acetyloxy)methyl)-2,2-dimethyl-1,3-dioxane-4-acetic acid, 1,1-dimethylethyl ester also called (4R-Cis)-6-((acetyloxy)methyl)-2,2-dimethyl-1,3-dioxane-4-acetic acid, tert - butyl ester, or tert - butyl (4R-Cis)-6-((acetyloxy)methyl)-2,2-dimethyl-1,3-dioxane-4-acetate CAS No . : 154026-95-6 is a key intermediate of Rosuvastatin Calcium which is the active pharmaceutical ingredient ( API ) of the block buster drug Cretor.
It was innovated by the Japanese drug maker Shionogi and cooperated the marketing with AstraZeneca. Rosuvastatin Calcium is the new generation of statins drugs after Lovastatin, Simvastatin and Atorvastatin. It is a fully synthesized product and used to treat high cholesterol and to prevent cardiovascular disease. Some persons also call it super statin to express its good effect. The annual sales of Crestor exceed US dollars 6.6 Billion in 2014. The first generic version of Crestor will launch in US in 2016.
There are several synthesis routes to manufacture this intermediate CAS No . : 154026-95-6 but some routes are protected by the patents in some countries including Europe, USA and China. We strictly obey the laws and our commercial products are manufactured without infringing such patents. But anyway, the buyers should know the patent status by themselves. We promise to supply the real route of synthesis to the buyers. The buyers should take the risks of patent infringement by themselves.
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