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145783 14 8,
1156491 10 9
CAS : 145783-14-8 Ticagrelor Intermediate C7H7Cl2N3O2S cGMP standard 99.0% min
Chemical Name : 4 , 6 - Dichloro - 5 - Nitro - 2 - propylthiopyrimidine
CAS No . : 145783-14-8
Synonyms : Pyrimidine , 4 , 6 - Dichloro - 5 - nitro - 2 - ( propylthio ) - ; 4 , 6 - Dichloro - 5 - nitro - 2 - ( propylsulfanyl ) pyrimidine ; 4 , 6 - Dichloro - 5 - nitro - 2 - ( propylsulfanyl ) pyrimidine ; 4 , 6 - Dichloro - 5 - nitro - 2 - ( propylsulfanyl ) pyrimidine
Molecular Formula : C7H7Cl2N3O2S
Molecular Weight : 266.96
Usage : Ticagrelor Intermediate
Ticagrelor is the active pharmaceutical ingredient of Brilinta, Brilique or Possia, which is used to prevent thrombotic events such as heart attack or stroke in people who has acute coronary syndrome or myocardial infarction with ST elevation. It is produced by AstraZeneca. On Dec 30, 2010, it was approved by Europe Commission and on July 20, 2011 approved by US FDA. The global anual sales of Brilinta/Brilique is more than USD1 billion.
4 , 6 - Dichloro - 5 - Nitro - 2 - propylthiopyrimidine CAS No . : 145783-14-8 is one of its intermediates. There are several synthesis routes to manufacture this intermediate but some routes are protected by the patents in some countries including Europe, USA and China. We strictly obey the laws and our commercial products are manufactured without infringing such patents. But anyway, the buyers should know the patent status by themselves. We promise to supply the real route of synthesis to the buyers. The buyers should take the risks of patent infringement by themselves.
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